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• Similar findings were reported by Gijsbers and colleagues,160 who found that males showed a higher pressure pain threshold when tested by a female versus a male experimenter, whereas females’ pain threshold was not influenced by the sex of the experimenter.
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• You haven't seen each other for just over a year since Marin went away after graduation.
• Male sex differentiation is known to require a delicate dosage balance among male determining genes, including SOX9.

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Cognitive/affective factors are important determinants of pain responses and likely contribute to sex differences in pain.289,335 The cognitive and affective mechanisms that have been investigated most widely in the context of sex and gender differences include coping processes, catastrophizing, and affective factors (eg, anxiety, depression). The following sections discuss the evidence regarding sex differences in the associations among psychological factors and pain report. A study of third- and fifth-grade children in Finland found that 32% reported a weekly musculoskeletal pain with significantly more girls reporting pain in chest (7%, 4%) and in the upper back (8%, 5%) compared with boys.278 Sex-related differences were not found for the lower back and neck pain.

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This confidentiality promotes a safe environment where users can be their most authentic selves. The most studied of the endogenous pain modulatory systems is the endogenous opioid system, and sex differences in the functioning of this system could arise based on several different mechanisms. First, sex differences could result from differences in the distribution, expression or sensitivity of opioid receptors in regions of the central nervous system involved in nociceptive processing. At rest, women have shown higher μ-opioid receptor binding in various cortical and subcortical brain regions than men,456 whereas men exhibited greater μ-opioid receptor binding in several brain regions than women in response to experimentally induced muscle pain. These sex differences in both resting and pain-related μ-opioid receptor binding may contribute not only to sex differences in basal pain perception but also to differences in sensitivity to opioid medications.

46,XX male syndrome was first described in ), and the Chicago consensus renamed of this syndrome as 46,XX testicular DSD in ). Most patients have normal male phenotypes at birth, and are usually diagnosed in late adolescence because of delayed puberty, gynecomastia, or infertility2). Approximately 15% of XX males have hypospadias, cryptorchidism, or more severe genital ambiguity13). All 46,XX males are infertile owing to the absence of the azoospermia factor region in the long arm of the Y chromosome14,15).

Several studies have addressed whether physical or psychological interventions differentially influence pain responses in men versus women, and these studies are summarized in the lower portion of Table 10. The majority of these studies (5/6, 81%) indicate that females exhibit more efficient pain inhibitory responses compared with males. For example, using an isometric handgrip exercise, pressure pain threshold was elevated in females but not males, suggesting that exercise-induced analgesia was greater in females.226 However, sex-related differences in pain modulation may be dependent on the type of stressor and pain modality. For example, in response to a laboratory public-speaking stressor, males exhibited a greater stress-related reduction in heat pain, whereas females showed a greater reduction with ischemic pain.45 Sternberg et al387 reported that cold pain was reduced in males during video game competition, whereas pain was more substantially reduced by physical exercise in females.